Today's Date: July 31, 2010

BioNeurology Products and Pipeline

Neurodegenerative Diseases

Alzheimer's Disease Abeta Aggregation Inhibitors
(with Transition Therapeutics)
Discovery Phase:
Scientific research conducted with the aim of developing a drug for a specific disease or medical condition.
Preclinical Phase:
Animal studies and laboratory tests to evaluate safety and efficacy, demonstrate activity of a product candidate and identify its chemical and physical properties.
Phase 1:
Clinical studies to test safety profile of drug in humans.
Phase 2:
Clinical studies conducted with groups of patients to determine preliminary efficacy, dosage and expanded evidence of safety.
Phase 3:
Large scale clinical studies conducted in patients to provide sufficient data for statistical proof of efficacy and safety.
Filed Phase:
Filed
Approved Phase:
Approved
Marketed Phase:
Marketed
Discovery Preclinical Phase 1 Phase 2 Phase 3 Filed Approved Marketed
ELND005
Alzheimer's Disease Secretase Inhibitors
Beta Secretase Research
Gamma Secretase Research
Gamma Secretase Inhibitor (ELND007)
Gamma Secretase Inhibitor (ELND006)
Parkinson's Disease
Parkinson's Research

Autoimmune Diseases

Multiple Sclerosis (with Biogen Idec)
TYSABRI® (natalizumab) (U.S.)
TYSABRI® (natalizumab) (EU)
TYSABRI® Subcutaneous
Crohn's Disease (with Biogen Idec)
TYSABRI® (natalizumab) (U.S.)
Multiple Myeloma (with Biogen Idec)
TYSABRI® (natalizumab)
Small Molecules natalizumab follow-ons
ELND002
Autoimmune Research

Specialty Business

Infectious Diseases
MAXIPIME® (cefepime hydrochloride for injection) (U.S.)

Alzheimer's Immunotherapy Programi

Bapineuzumab (AAB-001) Monoclonal Antibody Intravenous
Bapineuzumab (AAB-001) Monoclonal Antibody Subcutaneous
AAB-002 Monoclonal Antibody
ACC-001 Immunoconjugate

Tip: Roll your mouse over the bars above to get an explanation of the phase they are at in the Pipeline.

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i - JANSSEN Alzheimer Immunotherapy in collaboration with Pfizer. Elan retains an approximate one-quarter interest in the Alzheimer's Immunotherapy Program

TYSABRI is a registered trademark of Elan Pharmaceuticals, Inc. in the United States and of Elan Pharma International Ltd. in various countries outside the United States.

MAXIPIME is a registered trademark of Bristol-Myers Squibb Company and licensed exclusively in the U.S.to Elan Pharmaceuticals, Inc.

®2009 Elan Pharmaceuticals, Inc. ELN 022 0104